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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Breast Cancer Res Treat. 2012 Nov 18;137(1):93–107. doi: 10.1007/s10549-012-2332-x

Fig. 4. Comparison of global gene expression profiles of three LBH589-treated cancer cell lines.

Fig. 4

(A) Three cell lines (H295R, HeLa and MCF7her2) were treated with 50 nM LBH589 for 4 hours and gene expression analyzed by Affymetrix Human Gene 1.0 ST Array. Expression of 335 genes changed among all three cell lines after treatment. Genes with an FDR-adjusted p-value < 0.05 were considered to be differentially expressed and subjected to Venn analysis. Venn analysis was first performed by analyzing cell-line-specific alterations in differentially expressed genes in each cell line, and then by analyzing overlap between gene lists from different lines. (B) Gene network of down-regulated genes by LBH589. The most down-regulated network identified by Ingenuity Pathway Analysis contains 27 genes.