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A model for FOXM1’s role in thyroid cancer. Schematic representation of the molecular pathways linked to FOXM1 upregulation in ATC (+ and − refer to activating or inhibitory signals respectively) and gene targets whose expression is stimulated by FOXM1. This pathway can be therapeutically targeted at multiple levels; as shown here and in Ahmed et al. (2012), these levels include FOXM1 itself (thiostrepton) and PI3K (LY294002).
