Skip to main content
. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Probiotics Antimicrob Proteins. 2013 Jan 13;5(1):26–35. doi: 10.1007/s12602-012-9123-x

Table 1.

Cytotoxicity and antiviral activity of Subtilosin, Aciclovir (ACV) and Foscarnet (FOS) against HSV-1.

Compound
(MW)		 Structural
Formula		 IUPAC name Virus CC50
(µg/
mL)		 EC50(µg/
mL)		 SI
Subtilosin
*
(3398.9)		 graphic file with name nihms435430t1.jpg - HSV-1 tk+ 314 9.6 33
HSV-1 tk deficient 314 10 31
FOS
(300.04)		 graphic file with name nihms435430t2.jpg phosphonoformic acid
trisodium salt
hexahydrate		 HSV-1 tk+ 210 15 14
HSV-1 tk deficient - - -
ACV
(225.2)		 graphic file with name nihms435430t3.jpg 9-(2-
hydroxyetoxymetyl)
guanine		 HSV-1 tk+ 67 0.07 957
HSV-1 tk deficient 67 6.4 10.4

CC50 compound concentration required to reduce cell viability by 50%, as determined by the MTT method.

EC50: compound concentration required to reduce virus yield by 50%.

SI (selectivity index): ratio CC50 / EC50.

*

Structural formula of subtilosin reproduced from Marx et al. [32].