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. Author manuscript; available in PMC: 2013 Apr 28.
Published in final edited form as: Nat Med. 2012 Nov;18(11):1617–1619. doi: 10.1038/nm.2983

Figure 1. Derepression of IGF signaling–related genes and hypertrophic cardiomyopathy by SIRT6 deficiency.

Figure 1

Sundaresan et al.7 provide evidence to suggest that in healthy individuals SIRT6 suppresses IGF signaling–related genes by binding and silencing expression from AP1-dependent promoters, and this contributes to metabolic homeostasis and the maintenance of a healthy heart. Low expression of SIRT6 possibly caused by a high-fat diet, sedentary lifestyle and/or genetics results in reduced SIRT6 silencing, and overexpression of IGF and possibly also of other AP1-dependent genes, thus promoting cardiomyopathy, heart failure and early death. Ac, acetylated H3K9.