Table 1. Carotid Wall Measurements Change Over 3 Years and Differential Changes Between Slices With and Without LRNC.

	Comparison: Baseline vs. 3 Yrs				Annual Changes*				Comparison: Change Over 3 Yrs Slices LRNC (+) vs. LRNC (−)†
	n	Baseline	3 Yrs	p Value‡	n	1st Yr	2nd Yr	3rd Yr	n	LRNC (+)	LRNC (−)	p Value‡
Wall volume, mm3	33	641 ± 200	597 ± 198	<0.001	30	−16 ± 62	−42 ± 57§∥	3 ± 34	31	−45 ± 55¶	−11 ± 32	0.004
Percent wall volume, %	33	46.5 ± 7.1	44.3 ± 7.2	0.006	30	−0.6 ± 2.9	−2.1 ± 3.2§∥	−0.2 ± 2.5	31	−4.7 ± 7.1¶	−1.4 ± 3.2	0.020
Lumen volume, mm3	33	750 ± 249	764 ± 258	0.110	30	2 ± 50	18 ± 52	5 ± 42	31	12 ± 41	7 ± 40	0.300

Values are mean ± SD for the comparison of baseline versus 3 years and mean ± SE for each annual change during the 3 years.

^*Changes between the scans were annualized because of different times between the visits for different subjects. The calculation of changes was limited to patients with all 4 annual visits. Thus, the sample size is smaller than for the comparison of baseline versus 3 years.

^†The smaller sample size (n = 31) was the results of 2 patients not having both lipid-rich necrotic core (LRNC) positive (+) and LRNC negative (−) slices.

^‡Paired t test.

^§p < 0.001 when compared to null hypothesis of zero change.

^∥p ≤ 0.01 when compared to year 1.

^¶p < 0.001 when compared to zero change.