Skip to main content
. Author manuscript; available in PMC: 2013 Apr 28.
Published in final edited form as: Cell Metab. 2006 Jul;4(1):49–60. doi: 10.1016/j.cmet.2006.04.014

Figure 3.

Figure 3

Activation of STAT3 is required for leptin-dependent restoration of LH surges in starved female rats

A) Experimental protocol. Rats underwent ovariectomy and placement of the ICV cannula on day 1. After 7 days of recovery, vascular catheters were implanted and food was removed to begin a 3 day fast. On day 8 and 9 rats were primed with estradiol, and on day 10 they were injected with progesterone to trigger a LH surge.

B) Peak LH value after progesterone injection.

C) Serial measurements of LH levels from individual animals treated with ICV vehicle (upper panel), 2.5 μg of leptin (middle panel), and leptin (2.5 μg) plus the STAT3 PI (75 pmol) (lower panel).