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. Author manuscript; available in PMC: 2014 Jan 16.
Published in final edited form as: Cell Host Microbe. 2013 Jan 16;13(1):15–28. doi: 10.1016/j.chom.2012.12.001

Figure 6. Mammalian PKC Inhibitors Show Antiparasitic Activity In Vivo.

Figure 6

(A) P. yoelii parasitemia quantified via Giemsa tail vein blood smear upon intravenous injection of 10 mg/kg Gö6976 once daily for 4 days. (n = 10; ***p < 0.001).

(B) T. gondii parasite burden in cells from the spleen (top) and peritoneal cavity (PECS; bottom) upon intraperitoneal injection of 10 mg/kg Gö6976, quantified by flow cytometry. Plots shown are gated on single, live cells by FSC and SSC. (n = 15 for all conditions; ***p < 0.0001).

(C) P. berghei ANKA parasitemia quantified via Giemsa tail vein blood smear upon 50 mg/kg sotrastaurin treatment via gastric gavage once daily for 4 days. (n = 7 for all conditions; ***p < 0.0001). Shown are mean parasitemias ± SEM.

(D) Survival curves following sotrastaurin treatment using the standard Mantel-Cox log rank test (**p = 0.0029).