Table 1.

Summary of ultra high resolution optical coherence tomography optical signs of ocular surface lesions

	Epithelial layer		Subepithelial layers
	Thickness	Reflectivity
PAM	Normal	Moderately hyper-reflective with strong regular hyper- reflectivity of basal epithelium	No invasion in the sub-epithelial tissue layers
Amelanotic Melanoma	Normal or mildly thickened	Epithelial cleavage which indicates some involvement of the epithelium with atypical melanocytes.	Severely hyper-reflective sup-epithelial lesion Significant shadow obscuring the end point of the lesion
Nevi	Normal or mildly thickened	In compound nevi, lesion is seen in the epithelium and substantia propria.	Well circumscribed highly hyper-reflective lesion Confined to the substantia propria in subepithelial nevi Cysts within the subepithelial tissue Shadow casted may sometimes obscure the posterior border of the lesion
OSSN	Severely thickened	Hyper-reflective epithelium Abrupt transition between normal and affected epithelium. Cleavage plane between the lesion and underlying tissue may be seen in some lesions In large lesions a shadow from the hyper-reflective epithelium may obscure inferior border	Uninvolved in CCIN,
Conjunctival Histiocytosis	Normal	Normal	Well circumscribed lesion Stippled by small hyper-reflective dots suggestive of an infiltration Intralesional round and oval hypo-reflective areas suggestive of blood vessels.
Conjunctival Lymphoma	Normal	Normal	Homogenous, hypo-reflective and dark lesion Seemed to be formed of small stippled hyper-reflective dots suggestive of a homogenous cell population. Some shadow is casted by the mass on the underlying tissue.
Conjunctival Amyloidosis	Normal	Normal	Well demarcated from the underlying tissue. Lesion has both hypo-reflective areas with interspaced areas/lines of hyper-reflectivity. Inhomogeneous.
Pterygia	Normal	Moderate hyper-reflectivity or normal	Highly hyper-reflective fibrillary sub-epithelial demarcated layer under the conjunctival epithelium and present between the corneal epithelium and Bowman’s layer.

PAM: Conjunctival Primary Acquired Melanosis CCIN: Corneal and conjunctival intraepithelial neoplasia

OSSN: Ocular Surface Squamous Neoplasia