Figure 3.

Integrin α2 was down-regulated in osteogenesis of osteoporotic hBMSCs. A: Quantitative RT-PCR for mRNA levels of various integrin subunits. The expression of α2 and β1 was remarkably decreased in osteoporotic hBMSCs. B: The expression pattern of integrin α2, β1 and osteogenic master genes, Runx2 and Osterix is detected in hBMSCs isolated with differentiation from 3 days to 14 days. Results are shown as the relative expression to GAPDH (mean±SD), and significance is determined by Student’s t-test. (*, p<0.05; **, p<0.01 and ***, p<0.001).