Figure 3.

Summary of successive driver mutations in the natural course of the SCN → sMDS → sAML transition. (A) Counts N_i(t) of cells in successive mutant clones, under model as in Eq. 7 with A = 0.02, ε = 0.2, and k = 2. Straight lines with increasing slopes: counts of cells in successive mutant clones. Thick dashed line: Total mutant cell count. (B) Relative proportions n_i(t) = N_i(t)/Σ_jN_j(t) of cells belonging to successive mutant clones. Further details as in the Section “Mathematics of the Model.”