Table 1.

Summary of life histories of patients transitioning from severe congenital neutropenia (SCN) to secondary myelodysplastic syndrome (sMDS) to secondary acute myeloid leukemia (sAML) (Walter et al., 2012).

Phase of disease	Age at diagnosis (years)	Number of co-existing mutations
SCN	0–0.5	1*
MDS	1–12	1–3 ± chromosomal loss or gain**
AML	2–38	1–9 ± chromosomal loss or gain***

*ELANE, HAX1, G6PC, WAS, CSF3R.

**GCSF3R, ZC3H18, LLGL2; RAS ± monosomy 7.

***RUNX1, ASXL1, p300, CEBA, CSF3R, MGA,SUZ12, LAMB,FBXO18,CCDC15, ± monosomy 7, trisomy 21.