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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2012 Mar 23;7(3):499–518. doi: 10.1007/s11481-012-9352-5

Fig. 1.

Fig. 1

Schematic diagram showing connexin (Cxs) membrane topology and a plaque of GJ channels. a Model showing membrane topology of Cx E1 and E2, represent the extracellular loops and IL, the intracellular domain. b Model of the GJ plaque between two cells (cell 1-cell 2) and its role in mediating communication by diffusion of second messengers smaller than 1 kDa, such as Ca2+, IP3 and nucleotides