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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2012 Mar 23;7(3):499–518. doi: 10.1007/s11481-012-9352-5

Fig. 2.

Fig. 2

Cartoon representing some of the agents/conditions that open/close hemichannels and an electrophysiological recording of their activity. The arrows in the diagram show the different conditions that open hemichannels, such as positive voltages (+Vm), metabolic inhibition (MI) and changes in redox potential (dithio-treitol, DTT), and the conditions that close hemichannels, such as low pH and high extracellular calcium (high Ca2+). An example of an electrophysiological recording obtained in Hela cells transfected with Cx43-EGFP in whole cell patch, voltage clamp at +30 mV, is shown under metabolic inhibition conditions as described (Contreras et al. 2002)