Table 2.
Baseline Characteristics of Patients in SCD-HeFT vs SCD-HeFT–like Patients in the ICD Registry
| Characteristic | Patients in SCD-HeFT (n = 1676) | ICD Registry (n = 53 351)a | P Value for Difference From SCD-HeFT Patients | Matched ICD Registry Patients, No. (%)(n = 3352)a | P Value for Difference From SCD-HeFT Patients |
|---|---|---|---|---|---|
| Age, median (IQR) range, y | 60 (51–68) | 67 (57–75) | <.001 | 59 (51–67) | .41 |
| Male sex, No. (%) | 1294 (77) | 39 599 (74) | .005 | 2611 (78) | .58 |
| White race, No. (%) | 1283 (77) | 41 662 (78) | .11 | 2530 (76) | .43 |
| QRS duration, median (IQR), ms | 112 (96–140) | 106 (94–123) | <.001 | 110 (96–130) | .004 |
| Left ventricular ejection fraction, median (IQR), % | 25 (20–30) | 25 (20–30) | <.001 | 25 (20–30) | .50 |
| Mean (SD) | 23.7 (6.9) | 24.9 (6.4) | 23.9 (6.7) | ||
| NYHA class, No. (%) | <.001 | .26 | |||
| II | 1160 (69) | 31 975 (60) | 2372 (71) | ||
| III | 516 (31) | 21 376 (40) | 980 (29) | ||
| Ischemic heart disease, No. (%) | 884 (53) | 36 856 (69) | <.001 | 1760 (53) | .87 |
| Prior myocardial infarction, No. (%) | 760 (45) | 29 507 (55) | <.001 | 1520 (45) | .99 |
| Prior CABG, No. (%) | 449 (27) | 18 896 (35) | <.001 | 895 (27) | .94 |
| Prior PCI, No. (%) | 344 (21) | 18 099 (34) | <.001 | 685 (20) | .93 |
| Prior atrial arrhythmias, No. (%) | 258 (15) | 14 904 (28) | <.001 | 468 (14) | .18 |
| Prior ventricular arrhythmias, No. (%) | 390 (23) | 12 291 (23) | .82 | 801 (24) | .63 |
| Systolic blood pressure, median (IQR), mm Hg | 118 (106–132) | 129 (114–144) | <.001 | 118 (107–131) | .55 |
| Blood urea nitrogen, median (IQR), mg/dL | 19 (15–26) | 20 (15–28) | <.001 | 19 (15–25) | .54 |
| Creatinine, median (IQR), mg/dL | 1.1 (0.9–1.4) | 1.2 (1.0–1.4) | <.001 | 1.1 (0.9–1.3) | .55 |
| Diabetes, No. (%) | 524 (31) | 20 095 (38) | <.001 | 1023 (31) | .59 |
| Hypertension, No. (%) | 931 (56) | 40 413 (76) | <.001 | 1922 (57) | .23 |
| Medications at baseline, No. (%) ACE inhibitor or ARB |
1610 (96) | 42 189 (79) | <.001 | 3178 (95) | .06 |
| β-Blocker | 1157 (69) | 46 336 (87) | <.001 | 2533 (76) | <.001 |
| Calcium-channel blocker | 189 (11) | 4276 (8) | <.001 | 294 (9) | .005 |
| Digoxin | 1141 (68) | 14 480 (27) | <.001 | 2212 (66) | .14 |
| Diuretic | 1445 (86) | 34 969 (66) | <.001 | 2925 (87) | .29 |
| Statin | 631 (38) | 33 715 (63) | <.001 | 1346 (40) | .08 |
Abbreviations: ACE, angiotensin-converting enzyme; ARB angiotensin receptor blocker; CABG, coronary-artery bypass graft procedure; ICD, implantable cardioverter-defibrillator; IQR, interquartile range; NYHA, New York Heart Association; PCI, percutaneous coronary intervention; SCD-HeFT, Sudden Cardiac Death in Heart Failure Trial.
SI conversion factors: To convert blood urea nitrogen to mmol/L, multiply by 0.357; creatinine to 3mol/L, multiply by 88.4.
a
SCD-HeFT–like patients.