Table 3.

All-Cause Mortality in the Matched Groups

	Kaplan-Meier Mortality Rate, % (95% CI)			ICD Registry vs Trial Patients With ICDs		ICD Registry vs Trial Patients Receiving Medical Therapy
	Trial-like Registry Patients	ICD-Randomized Trial Patients	Medical Therapy–Randomized Trial Patients	Adjusted HR (95% CI)	P Value	Adjusted HR (95% CI)	P Value
All Patients
MADIT-II
Year 1	7.3 (6.2–8.3)	8.9 (6.7–11.1)	10.2 (7.4–13.1)	1.06 (0.85–1.31)	.62	0.73 (0.59–0.92)	.007
Year 2	13.9 (12.6–15.3)	15.6 (12.4–18.7)	22.0 (17.6–26.4)
Total deaths, No.	507	105	97
Patients, No.	2464	742	490
SCD-HeFT
Year 1	5.6 (4.8–6.4)	6.2 (4.5–7.8)	5.9 (4.3–7.5)	1.16 (0.97–1.38)	.11	0.82 (0.70–0.96)	.01
Year 2	11.3 (10.3–12.4)	11.7 (9.5–13.9)	14.5 (12.1–16.9)
Year 3	17.3 (16.0–18.7)	17.4 (14.7–20.0)	22.4 (19.5–25.2)
Total deaths, No.	588	182	244
Patients, No.	3352	829	847
Patients ≥65 y
MADIT-II
Year 1	9.2 (7.6–10.8)	10.8 (7.5–14.1)	14.1 (9.6–18.7)	1.02 (0.78–1.33)	.88	0.65 (0.49–0.85)	.002
Year 2	16.5 (14.5–18.5)	19.8 (14.9–24.7)	31.5 (24.6–38.5)
Total deaths, No.	333	70	70
Patients, No.	1306	397	262
SCD-HeFT
Year 1	7.1 (5.6–8.6)	8.8 (5.6–12.1)	7.7 (4.6–10.9)	1.05 (0.81–1.36)	.73	0.76 (0.60–0.96)	.02
Year 2	14.8 (12.7–16.8)	16.0 (11.8–20.2)	18.7 (14.1–23.2)
Year 3	21.8 (19.2–24.4)	24.8 (19.7–29.9)	30.2 (24.8–35.7)
Total deaths, No.	255	94	107
Patients, No.	1132	294	284

Abbreviations: HR, hazard ratio; ICD, implantable cardioverter-defibrillator; MADIT-II, Multicenter Automatic Defibrillator Implantation Trial II; SCD-HeFT, Sudden Cardiac Death in Heart Failure Trial.