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. 2013 Feb 22;56(6):2429–2446. doi: 10.1021/jm3017656

Table 4. Inhibitory Effects of Compounds on Other AKR1C Enzymes.

    IC50 values (μM)
compdsa AKR1C3 AKR1C1 AKR1C2 AKR1C4
2 0.16 >100 (>625)b 54.50 (336) >100 (>625)
3 0.12 100 (833) 40.74 (329) 49.75 (415)
5 0.27 >100 (>370) 35.73 (134) >100 (>370)
15 0.74 >100 (>135) 81.0 (108) >100 (>135)
16 0.22 >100 (>455) 57.0 (257) >100 (>455)
20 0.96 >100 (>100) 100 (100) 48.7 (357)
27 0.21 >100 (>478) 50.13 (240) >100 (>478)
44 0.13 17.73 (136) 14.45 (111) 3.51 (27)
47 0.09 30.71 (341) 49.57 (538) 1.95 (22)
50 0.34 100 (296) 93.0 (275) 12.64 (37)
61 0.16 76.25 (477) 53.50 (331) 3.15 (20)
a

AKR1C3 and AKR1C2 data were taken from Tables 1–3 above.

b

Values in parentheses are IC50 ratios and represent inhibitor selectivity for AKR1C3 over other AKR1C enzymes.