Fig 2.

Clustered heatmap of transcripts associated with chemotherapy-induced heart failure. Transcript profiles of blood from women with breast cancer who did (Group A) or did not (Group B) develop low EFs were compared to identify differentially-expressed genes (DEGs) by a combined fold-change (>1.5 fold) and t-test (p<0.05) filtering. To exclude transcripts that were associated with heart failure in women not receiving doxorubicin, women with breast cancer and normal cardiac performance were sampled prior to chemotherapy (Group D) and compared to women with low EFs but who never received chemotherapy (Group C). The resulting 201 transcripts were clustered by their expression pattern across the 4 groups with each row indicating one transcript. Red indicates increased expression, blue indicates decreased expression, with yellow indicating little or no change.