Skip to main content
. Author manuscript; available in PMC: 2013 Apr 29.
Published in final edited form as: Nature. 2007 Jul 25;448(7155):816–819. doi: 10.1038/nature06042

Figure 1. Involvement of RNase L in induction of IFN-β expression by 2-5A, dsRNA or viral infection.

Figure 1

a–c, IFN-β concentration from wild-type (WT) or RNase L-deficient MEFs that were mock transfected (Control) or transfected with (2′-5′)A3 or (2′-5′) p3A3 for 16 h (a); mock transfected or transfected with poly(I):poly(C) for 18 h (b); or mock infected or infected with SeV for 18 h (c). d–f, IFN-β concentration from wild-type MEFs and RIG-I-deficient MEFs (d), MDA5-deficient MEFs (e) or IPS-1-deficient MEFs that were either mock transfected or transfected with unfractionated 2-5A for 16 h (f). Values are means from triplicate assays with standard deviations (s.d.).