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. Author manuscript; available in PMC: 2013 Apr 29.
Published in final edited form as: Nature. 2007 Jul 25;448(7155):816–819. doi: 10.1038/nature06042

Figure 4. RNase L contributes to induction of IFN-β by virus or 2-5A in vivo.

Figure 4

Serum levels of IFN-β from RNase L-deficient or wild-type mice infected with EMCV (a) or SeV for the indicated times (b), or injected intraperitoneally with 2-5A or mock-treated for 5 h (c). Horizontal lines show mean levels of IFN-β. Two-tailed, paired Student’s t-tests were performed. d, Model for transcriptional activation of the IFN-β gene by small RNAs produced by cleavage of cellular (self) RNA with RNase L. Red, IFN-inducible proteins; 2′-PDE, 2′-phosphodiesterase; OAS, 2′-5′-oligoadenylate synthetase.