Figure 3.

Transcriptional activity of C9orf72 promoter with alleles of different repeat length. Bars represent relative Gaussia/Cypridina luciferase activities (RLA) for the different C9orf72 constructs compared with the wild-type allele of 2 units, for an increasing amount of repeat units. Values represent the mean (±SDEV) of 36 independent measurements relative to the 2 units wild-type allele. The significance of differences in expression was calculated using the Mann–Whitney U test. P values are presented above the bars.