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. 2013 May;15(5):461–471. doi: 10.1593/neo.121024

Figure 5.

Figure 5

Pten deletion induces angiogenesis and up-regulation of pAKT activity and COX-2 expression in epithelial dysplasias and oral tumors. (A) Blood vessel density was detected by factor VIII staining and defined as number of blood vessels per field. Micrographs are representative examples of blood vessels stained with factor VIII (arrow) in oral tissue from control, K14Cre PtenF/+, and K14Cre PtenF/F mice (***P < .001). (B) Oral dysplasias and tumors induced by the tobacco surrogate (4NQO) with Pten deregulation (K14Cre PtenF/F) display up-regulation of pAKTSer473 and COX-2, the latter in both the epithelial cells and the tumor stroma, and do not involve the accumulation of mutant p53.