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INZ significantly enhances the proapoptotic effect of CIS on H460 and HCT116 cells. H460 (A) and HCT116p53+/+ (B) were plated in 6-cm-diameter dishes and treated with INZ or/and CIS at the indicated concentrations for 48 hours. Cells were stained with PI and subjected to flow cytometry to determine the DNA content. The apoptotic cells, identified by sub-G1 DNA content, were presented as the M1 population. The data were expressed as means ± SEM (n = 4).
