Figure 2.

Effect of acute mirtazapine administration (15 mg orally) on amygdala response to emotional faces. (a) Axial, coronal and sagittal images depicting significantly increased activation in placebos for the contrast fear versus happy facial expressions (images thresholded at Z = 2.0, p = 0.05, corrected) in the right temporal cortex, extending to hippocampus and amygdala (peak voxel 28, −18, −18). (b) BOLD percent signal change extracted from the significant cluster in the right temporal cortex to fear and happy faces. Error bars show s.e.m. **p < 0.01. Adapted from Rawlings et al. [32] with permission.