Figure 7.

Increased ATP release in the gut during GVHD in mice. Extracellular ATP levels were revealed by HEK293-pmeLUC cells injected intravenously in BALB/c mice that were either untreated or had received irradiation and allogeneic bone marrow alone (BM), or BM together with allogeneic T cells (BM+Tc), or BM with allogeneic T cells and apyrase (BM+Tc+apyrase). These data indicate that the ATP level increases in the gut during GVHD. ATP increase is abrogated by apyrase (adapted from Wilhelm et al. [48]).