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Model 1 simulated time course of dppERKnuc response to 30 pM NGF (solid line). The dashed line shows the response in the presence of a TrkA binding inhibitor given at t = 0, Ki = 0.1 nM (at 1000×Kd of the inhibitor) and the dashed-dotted line at 1×10 000×Ki. (Online version in colour.)
