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Model 3 simulations with and without hypothetical inhibitor of TrkA kinase, given at t = 0, Ki = 0.1 nM. Graph shows the accumulation of phosphorylated-NGF–TrkA complex concentration in the neuronal compartment over time with and without TrkA inhibitor. No inhibitor (solid line) 10×Ki (dashed line) 100×Ki (dashed-dotted line). (Online version in colour.)
