Figure 5.
Heterogeneity of tension development after length- and tension-dependent feedback on length-dependent activation properties. Simulation results showing (a) decreased heterogeneity after length-dependent feedback; (b) a larger decrease in heterogeneity after tension-dependent feedback. Both results are shown 55 ms into the 30th heart beat, near peak tension levels. (a,b) Show tension development throughout the heart beat; (c,d) show the heterogeneity near peak tension; and (e,f) show the adjustment in length-dependent activation Δλ. Details of the model equations are shown in the electronic supplementary material, §S2.2.