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Evolution of a cluster containing multiple cell types. In the figure, the blue cells are normal cells, red cells are tumour while the remaining ones (light green) are the quiescent tumour cells. (a) Initial stage: time = 0 h, (b) cells begin proliferation: time = 100 h, (c) death of cells in the hypoxic region: time = 300 h and (d) further cell proliferation and growing hypoxic region: time = 500 h.
