Table 1.

Summary of Model Parameters

Parameter	Definition	Reported value or units	Source
C	Dissolved oxygen concentration in gel	% or mol/m3	-
Cb	Oxygen concentration at air-gel boundary	% or mol/m3	-
Co	Initial oxygen concentration in gel	% or mol/m3	-
z	Distance from air-gel boundary	m	-
h	Gel thickness	m	-
t	Time in culture	s	-
D	Oxygen diffusion coefficient in fibrin	1.7×10−9 m2/s	measured
Vmax	Maximum oxygen consumption rate	1.3×10−17 mol cell−1 s−1	measured
Km	Half-maximum rate oxygen concentration	8.0×10−3 mol/m3	measured
ρcell	Volumetric cell density	2.85×106 cells/mL	measured
So2	Solubility coefficient of oxygen in culture medium at 37°C	1.3×10−3 mol m−3 Torr−1	32
θ	Dimensionless concentration	-	-
τ	Dimensionless time	-	-
ζ	Dimensionless length	-	-
φ	Thiele modulus	-	-
Ceq	Oxygen concentration at equilibrium	% or mol/m3	-
Cmin,eq	Minimum oxygen concentration at equilibrium	% or mol/m3	-
Cmin	Minimum oxygen concentration	% or mol/m3	-
t90	Time to 90% equilibrium	s	-