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. 2013 Jun 10;18(17):2352–2363. doi: 10.1089/ars.2012.4834

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Copyright 2013, Mary Ann Liebert, Inc.

PMC Copyright notice

FIG. 3. — A disintegrin and metalloproteinase 17 (ADAM17)/tumor necrosis factor (TNF)-α converting enzyme (TACE)-mediated shedding of CD163 and TNF-α upon stimulation by proinflammatory stimuli. CD163 and proTNF-α are rapidly cleaved from the surface of activated macrophages by an ADAM17/TACE-dependent mechanism. A number of proinflammatory substances induce ADAM17/TACE activation. The exact site of cleavage in CD163 awaits identification. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars.