FIG. 5.
Using CD163 as a target for directed drug delivery. The endocytic property of CD163 allows either ligand- or antibody-associated drugs to have an easy and specific access to cytosolic compartment of macrophages. The figure shows examples of two types of conjugates: CD163 antibody- or ligand-drug conjugates and drugs encapsulated in pegylated liposomes with a CD163-binding antibody or ligand linked to the phospholipid layer. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars.