Table 1.
Effects of VtR on the serum levels of biochemical markers in OVX mice.
| Groups | Osteocalcin (ng/mL) | CTx (ng/mL) |
RANKL/OPG (ratio) |
IL-7 (pg/mL) |
|---|---|---|---|---|
| SHAM | 17.1 ± 1.5 | 16.4 ± 0.4 | 0.31 ± 0.02 | 0.32 ± 0.05 |
| OVX | 23.7 ± 1.4# | 19.8 ± 0.5## | 0.83 ± 0.04## | 1.67 ± 0.13## |
| OVX-VtR-50 | 22.5 ± 2.2 | 18.6 ± 0.6 | 0.88 ± 0.08 | 1.53 ± 0.28 |
| OVX-VtR-75 | 27.6 ± 1.7* | 16.9 ± 0.7* | 0.72 ± 0.03* | 0.52 ± 0.19** |
| OVX-VtR-100 | 29.3 ± 2.0** | 16.3 ± 0.9** | 0.42 ± 0.06** | 0.39 ± 0.12*** |
| OVX-E | 19.4 ± 2.6* | 16.4 ± 0.5 | 0.38 ± 0.07** | 0.27 ± 0.08*** |
Serum levels of biochemical markers in sham-operated mice (SHAM), ovariectomized mice administrated with vehicle (OVX), different dosages (50, 75, and 100 mg/kg) of VtR (OVX-VtR-50, -VtR-75, and -VtR-100), or 17β-estradiol (OVX-E) for 8 weeks. The values represent the means ± S.E.M. # P < 0.05 and ## P < 0.01, versus sham control; *P < 0.05, **P < 0.01, and ***P < 0.001, versus OVX. n = 8–10 samples per group.