Table 6.
The information of changed pathways in serum of four ZHNEGs.
| Label | Group | Classa | P valueb |
|---|---|---|---|
| Alanine, aspartate, and glutamate metabolism | S-DHHB | Amino acid metabolism | 0.02 |
| Arginine and proline metabolism | S-DHHB | Amino acid metabolism | 0.00 |
| Glycine, serine, and threonine metabolism | S-DHHB | Amino acid metabolism | 0.01 |
| Lysine biosynthesis | S-DHHB | Amino acid metabolism | 0.03 |
| Lysine degradation | S-DHHB | Amino acid metabolism | 0.00 |
| Phenylalanine, tyrosine, and tryptophan biosynthesis | S-DHHB | Amino acid metabolism | 0.02 |
| Novobiocin biosynthesis | S-DHHB | Biosynthesis of other secondary metabolites | 0.03 |
| Streptomycin biosynthesis | S-DHHB | Biosynthesis of other secondary metabolites | 0.02 |
| Galactose metabolism | S-DHHB | Carbohydrate metabolism | 0.00 |
| Nitrogen metabolism | S-DHHB | Energy metabolism | 0.00 |
| Biosynthesis of unsaturated fatty acids | S-DHHB | Lipid metabolism | 0.00 |
| Fatty acid biosynthesis | S-DHHB | Lipid metabolism | 0.06 |
| Thiamine metabolism | S-DHHB | Metabolism of cofactors and vitamins | 0.02 |
| Cyanoamino acid metabolism | S-DHHB | Metabolism of other amino acids | 0.00 |
| Glutathione metabolism | S-DHHB | Metabolism of other amino acids | 0.00 |
| Pyrimidine metabolism | S-DHHB | Nucleotide metabolism | 0.08 |
| ABC transporters | S-DHHB | Signal transduction | 0.00 |
| Aminoacyl-tRNA biosynthesis | S-DHHB | Signal transduction | 0.00 |
| Two-component system | S-DHHB | Signal transduction | 0.02 |
| ABC transporters | S-DHHB | Signal transduction | 0.01 |
| Arginine and proline metabolism | S-NDHHB | Amino acid metabolism | 0.00 |
| Glycine, serine, and threonine metabolism | S-NDHHB | Amino acid metabolism | 0.03 |
| Lysine degradation | S-NDHHB | Amino acid metabolism | 0.03 |
| Galactose metabolism | S-NDHHB | Carbohydrate metabolism | 0.02 |
| Pentose and glucuronate interconversions | S-NDHHB | Carbohydrate metabolism | 0.00 |
| Biosynthesis of unsaturated fatty acids | S-NDHHB | Lipid metabolism | 0.00 |
| Fatty acid biosynthesis | S-NDHHB | Lipid metabolism | 0.03 |
| Nicotinate and nicotinamide metabolism | S-NDHHB | Metabolism of cofactors and vitamins | 0.03 |
| Glutathione metabolism | S-NDHHB | Metabolism of other amino acids | 0.00 |
| ABC transporters | S-NDHHB | Signal transduction | 0.00 |
| Aminoacyl-tRNA biosynthesis | S-NDHHB | Signal transduction | 0.01 |
| Arginine and proline metabolism | S-DHFL | Amino acid metabolism | 0.06 |
| Lysine degradation | S-DHFL | Amino acid metabolism | 0.02 |
| Glycolysis/Gluconeogenesis | S-DHFL | Carbohydrate metabolism | 0.01 |
| Nitrogen metabolism | S-DHFL | Energy metabolism | 0.01 |
| Thiamine metabolism | S-DHFL | Metabolism of cofactors and vitamins | 0.01 |
| Cyanoamino acid metabolism | S-DHFL | Metabolism of other amino acids | 0.00 |
| Glutathione metabolism | S-DHFL | Metabolism of other amino acids | 0.01 |
| Purine metabolism | S-DHFL | Nucleotide metabolism | 0.01 |
| ABC transporters | S-DHFL | Signal transduction | 0.00 |
| Aminoacyl-tRNA biosynthesis | S-DHFL | Signal transduction | 0.00 |
| Biosynthesis of unsaturated fatty acids | S-NDHFL | Lipid metabolism | 0.00 |
| Fatty acid biosynthesis | S-NDHFL | Lipid metabolism | 0.00 |
| ABC transporters | S-NDHFL | Signal transduction | 0.01 |
| Aminoacyl-tRNA biosynthesis | S-NDHFL | Signal transduction | 0.01 |
aThe classes are categorized by KEGG.
b P value is obtained from analysis of MBRole.