Figure 3.

Effects of intraperitoneal administration of a combination of a GLP-1 receptor agonist, exendin-4 (Ex 4), and a cannabinoid CB1 receptor agonist, WIN 55,212-2 (WIN), on daily food intake (panel A) and body weight changes (panel B) in the rat. The initial values in panel A are the mean food consumption during two consecutive days before the injection of the drug. The subsequent measurements were made 24 and 48 hours after injections. Body weight in all groups was measured on the day of injection and compared to results obtained 24 and 48 hours after the injection. Data are mean ±SEM. * p<0.01; ** p<0.001.