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Age-dependent differences in cell autonomous immunity to L. monocytogenes.
| Effector | Role in listeriosis | Neonatal mouse | Neonatal human |
|---|---|---|---|
| Recognition of L. monocytogenes | (i) TLR/Myd88 | ? | ? |
| (ii) Cytosolic surveillance | ? | ? | |
| (iii) Inflammasome | ? | ? | |
| Intracellular fate of L. monocytogenes | (i) Phagocytosis | ? | ? |
| (ii) Autophagy | ? | ? | |
| (iii) IFN-inducible GTPases | ? | ? | |
| Fate of L. monocytogenes-infected monocyte | (i) Apoptosis | ? | ? |
| (ii) Necrosis | ? | ? | |
| (iii) Pyroptosis | ? | ? |
