Table 5.
Upregulation frequency for genes targeted by ‘non-FDA-approved chemical agents’
| Targeted protein symbol | Targeted protein | Non-FDA-approved chemical agents | Frequency (n = 78) |
|---|---|---|---|
| CDK1 | Cyclin-dependent kinase I | Alvocidlib, Seliciclib | 33 |
| PRKDC | Protein kinase, DNA-dependent | IC88821, NU7026 | 32 |
| CSNK2A1 | Casein kinase II | Myricetin | 31 |
| PRKCI | Protein kinase C I | HA-100, ML-7 | 31 |
| GAPDH | GAPDH | Iodoacetic acid | 30 |
| CDK2 | Cyclin-dependent kinase 2 | Alvocidlib, Seliciclib | 29 |
| CASP2 | Caspase II | Fluoromethyl ketone | 29 |
| CSNK1A1 | Casein kinase I | IC 261 | 29 |
| MMP11 | Matrix metalloprotease 11 | Bipyridyl reagentPlus | 28 |
| POLR2H | RNA polymerase | Thiolutin | 28 |
| SQLE | Squalene epoxidase | Terbinafine hydrochloride | 28 |
| KRAS | Rat sarcoma viral oncogene | Tipifarnib, Lonafarnib | 27 |
| CLK2 | Cdc2-like kinase | TG003 | 27 |
| HSP90AA1 | Heat shock protein | Tanespimycin | 27 |
| MMP14 | Matrix metalloprotease 14 | Bipyridyl ReagentPlus | 27 |
| CASP3 | Caspase 3 | Fluoromethyl ketone | 27 |
| POLR2G | RNA polymerase | Thiolutin | 27 |
| PARP1 | Poly (ADP-ribose) polymerase | BSI-201, Olaparib | 26 |
| CDK7 | Cyclin-dependent kinase 7 | Alvocidlib, Seliciclib | 26 |
| HSP90AB1 | Heat shock protein | Tanespimycin | 26 |
Abbreviation: n, number of tests.