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. Author manuscript; available in PMC: 2014 May 10.
Published in final edited form as: J Control Release. 2013 Feb 26;167(3):221–227. doi: 10.1016/j.jconrel.2013.02.007

Figure 2. 5-ALA prodrug, in combination with light treatment, is an effective phototoxic agent that selectively and sensitively induces cell death in vitro.

Figure 2

Microscopic image of unfixed human pancreatic cancer cells (MPanc96-CTSE) untreated (top) and treated with 0.1 μM 5-ALA prodrug (bottom), before (a, c) and after (b, d) illumination with doses of 18 J/cm2 (top) and 10 J/cm2 (bottom). The cells show no sign of morphological changes upon exposure to high doses of light alone. However, massive cell destruction is observed upon treatment with the 5-ALA prodrug and exposure to a low dose of light.