Table 3.

The association of regional screening-related cost and breast cancer incidence and treatment cost

		Overall Incidence		In Situ or Stage 1 Incidence		Stage IV Incidence		Treatment Coste (per beneficiary)
	Quartile	Annual Incidencec	IRRd (95% CI)	Annual Incidence	IRR (95% CI)	Annual Incidence	IRR (95% CI)	Cost	P-value
Screening + Work-Up Costa (per beneficiary)	1	3.3	REF	1.8	REF	0.2	REF	$115	REF
	2	4.7	1.34 (1.13–1.60)	2.5	1.41 (1.11–1.80)	0.2	0.87 (0.45–1.71)	$157	.37
	3	5.0	1.40 (1.17–1.68)	2.7	1.48 (1.16–1.90)	0.3	1.11 (0.57–2.17)	$136	.50
	4	4.6	1.54 (1.29–1.84)	2.8	1.78 (1.40–2.26)	0.2	0.84 (0.40–1.75)	$151	.20
Screening + Work-Up Costb (per screened beneficiary)	1	3.6	REF	1.8	REF	0.2	REF	$148	REF
	2	4.1	1.12 (0.94–1.34)	2.3	1.35 (1.06–1.71)	0.3	0.68 (0.34–1.36)	$138	.96
	3	5.1	1.29 (1.09–1.52)	2.8	1.44 (1.14–1.82)	0.3	(00.98.53–1.83)	$116	.55
	4	4.8	1.35 (1.14–1.60)	2.9	1.66 (1.32–2.09)	0.2	0.70 (0.35–1.43)	$161	.73

^a1st quartile screening + work-up cost per beneficiary: <$57, 2nd quartile: $57–64, 3rd quartile: $65–70, 4th quartile: >$70

^b1st quartile screening + work-up cost per screened beneficiary: <$121, 2nd quartile $121–131, 3rd quartile: $131–143, 4th quartile: > $143

^cAnnual Incidence per 1,000 person-years

^dIncidence Rate Ratio (IRR) adjusted for age, race, comorbidity, and income

^eTreatment cost p-value adjusted for mean age, income, percent white, and average annual total Medicare expenditures per capita of health referral region.