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The antioxidant protein network in Schistosoma mansoni. TGR catalyzes deglutathionylation reactions of proteins and peptides(1). In addition, TGR not only reduces GSSG and oxidized Trx but also low molecular weight compounds (e.g., hydrogen peroxide)(2) utilizing NADPH. Prx proteins can receive electrons from either Trx or GSH to neutralize H2O2 and lipid peroxides.
