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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Mar 5;1833(6):1489–1497. doi: 10.1016/j.bbamcr.2013.02.026

Figure 2. DDX3 regulates DNA damage-induced apoptosis in a manner dependent on the functional status of p53.

Figure 2

Figure 2

p-p38, p38 and p-JNK levels were measured in wild-type (WT) and DDX3 knockdown (KD) (A) MCF-7 cells and (B) HeLa cells following treatment with 10 μM camptothecin for the indicated time points. Intact procaspase-8 (55/53 kDa) and cleaved 43/41 kDa caspase-8 and β-actin levels were measured after HeLa (C) and BJAB (D) cells were treated with 10 μM camptothecin for the indicated time points. Experiments were repeated at least two times with similar results. Cell survival was examined after treatment with 0, 0.1, 1, and 10 μM camptothecin for 24 hr in (E) MCF-7 cells, (F) HeLa cells, and (G) MDA-MB-231 cells with DDX3 (WT) and with DDX3 knocked down (KD). Means ± SEM; n=3; *p<0.05.