Figure 1.
Mean change in plasma concentrations of TNF-α (tumor necrosis factor-α) and IL-6 (interleukin-6) at baseline, 1 week and 12 weeks in CF (cystic fibrosis) adults randomized to 250 000 IU cholecalciferol or placebo. (a) Mean change in TNF-α plasma concentrations. In the vitamin D group, TNF-α decreased 3.56 and 27.83 pg/ml at 1 week and 12 weeks (P = 0.6, 0.0002); TNF-α remained unchanged in the placebo. (SEM bars). (b) Mean change in plasma concentrations of IL-6. In the vitamin D group, IL-6 decreased 12.39 and 5.16 pg/ml at 1 week and 12 weeks (P = 0.004, 0.35); IL-6 remained unchanged in the placebo (SEM bars).