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. 2013 Apr 24;123(5):2143–2154. doi: 10.1172/JCI64365

Figure 5. miR-146a is elevated in plasma and LV tissue of patients with acute PPCM compared with controls and DCM and is reduced after recovery.

Figure 5

(A) Ratio between miR-146a and 2 spike-in miRNAs (cel-39 and cel-238) in plasma from patients with acute PPCM (n = 38), postpartum-matched (PP-matched) healthy controls (n = 18), age-matched healthy controls (n = 5), DCM patients (n = 30), and recovered PPCM patients treated with standard heart failure therapy and bromocriptine (n = 12). **P < 0.01, ***P < 0.001 vs. PPCM. (B) Follow-up ratio between miR-146a and 2 spike-in miRNAs in plasma from 7 PPCM patients, at baseline and after treatment with standard therapy for heart failure and bromocriptine. **P < 0.01 vs. PPCM. (C) qRT-PCR of miR-146a in LVs from PPCM patients (n = 3), DCM patients (n = 8), and nonfailing organ donors (NF; n = 4). (D) Level of ERBB4 mRNA in LVs from PPCM patients (n = 3) and nonfailing organ donors (n = 4). *P < 0.05 vs. nonfailing; #P < 0.005 vs. PPCM. Data are mean ± SEM.