. Author manuscript; available in PMC: 2013 Apr 29.

Published in final edited form as: J Steroid Biochem Mol Biol. 2007 Sep 7;108(0):23–31. doi: 10.1016/j.jsbmb.2007.07.001

Table 1. Relative binding affinities (RBA) of the synthetic isoflavones and genistein (GEN) for ERα and ERβ.

For each binding assay, RBA of a specific ligand was calculated by dividing the IC₅₀ of E₂ by the IC₅₀ of the tested compound and expressed as percent.


Compound	X	R1	R2	R3	RBA (ERα)	RBA (ERβ)
1	S	OH	OH	OH	0.01	0.19
2	O	OH	OH	OH	0.34	0.66
4	O	OH	OH	2-(1-piperidin-1-yl)ethoxy	14.7	1.66
5	S	OMe	OH	2-(1-piperidin-1-yl)ethoxy	0.02	no binding
6	O	OMe	OH	2-(1-piperidin-1-yl)ethoxy	3.1	0.87
GEN					1.26	16.8
E₂					100	100