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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Circ Res. 2013 Feb 1;112(3):549–561. doi: 10.1161/CIRCRESAHA.111.249243

Figure 2.

Figure 2

Mechanisms for generating minor histocompatibility antigens in pluripotent stem cells. Polymorphisms induced in ES and iPS cells can result in expression of proteins and peptides that are distinct from those in the donor cells. Upon proteolytic degradation, these peptides are transported by the peptide transporter into the endoplasmic reticulum (ER), where they can bind to HLA molecules and pass through the Golgi apparatus to be presented at the cell surface as a complex with HLA and be recognized as foreign by donor T cells.