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Notch signaling is required for somitogenesis. (A) Anteroposterior X-ray of a patient with SCD due to a mutation in DLL3 courtesy of Dr. Peter Turnpenny. The thoracic and cervical spine have severe vertebral segmentation defects including hemivertebrae. (B) A negative feedback loop consisting of the Mesp2, Lfng, Hes7 and Dll3 genes regulate Notch signaling activity during somitogenesis.
