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. 2012 Jan 13;22(4):547–561. doi: 10.1111/j.1750-3639.2011.00557.x

Figure 6.

Figure 6

A18 AD: Laminar distribution of perineuronal nets (PNs) detected by Wisteria floribunda lectin (WFA) in area 18 of human Alzheimer's disease (AD) brain. Two key pathology markers, hyperphosphorylated tau (Tau) and amyloid beta (Aβ) are shown to demonstrate the basic laminar pathology profile. Wisteria floribunda lectin (WFA) indicates N‐acetylgalactosamine‐containing PNs in layer III and V. Low numbers of PNs can be seen in layer VI. This laminar distribution resembles the distribution pattern in control brain. Tau pathology to some extent overlaps with PN‐rich layers but PN‐ensheathed neurons invariably are devoid of tau pathology, whereas no obvious relation of amyloid plaque distribution and presence of PNs is detectable. The open circle marks the lower edge of layer IV. Scale bar = 200 µm.