Table 1.
Profile of cases. Abbrevations: AD = Alzheimer's disease; PMD = post‐mortem delay; CERAD = Consortium to Establish a Registry For Alzheimer's Disease (0 none, A sparse, B moderate, C frequent); Co = control; COD = cause of death; COPD = chronic obstructive pulmonary disease; F = female; HlD = high likelihood of dementia; M = male; MMSE = mini‐mental state examination; NIA = National Institute on Aging.
| Case # | PMD (h) | Gender | Age (years) | Brain weight (g) | COD | Braak score | MMSE (last) | CERAD neuritic plaque score | CERAD criteria | NIA criteria | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | 1 | 2.75 | F | 85 | 1020 | Pancreatic cancer | II | — | 0 | Not met | Not met |
| 2 | 1 | F | 85 | 1085 | Abdominal lymphoma | II | — | 0 | Not met | Not met | |
| 3 | 2.5 | F | 86 | 1145 | Pulmonary fibrosis | III | 27/30 | 0 | Not met | Not met | |
| 4 | 3 | F | 89 | 1200 | Congestive heart failure | III | 30/30 | A | Not met | Not met | |
| 5 | 2.75 | F | 75 | 1110 | Pulmonary embolus | III | 29/30 | 0 | Not met | Not met | |
| 6 | 2.5 | F | 87 | 1120 | Pneumonia/cancer | IV | 30/30 | 0 | Not met | Not met | |
| 7 | 2.5 | M | 74 | 1230 | Cardiac/respiratory failure | II | — | 0 | Not met | Not met | |
| 8 | 2.75 | M | 81 | 1290 | Cardiac/respiratory failure | I | — | 0 | Not met | Not met | |
| 9 | 1.66 | M | 78 | 1460 | Lung cancer/heart failure | I | 28/30 | 0 | Not met | Not met | |
| 10 | 3 | M | 82 | 1240 | Renal failure/COPD | III | 26/30 | A | Not met | Not met | |
| 11 | 4.75 | M | 86 | 1400 | Cardiac arrest | I | 28/30 | 0 | Not met | Not met | |
| 12 | 5.5 | M | 89 | 1275 | COPD/respiratory distress | II | 30/30 | 0 | Not met | Not met | |
| Mean | 2.89 | 6/6 | 83.1 | 1214 | |||||||
| AD | 13 | 3 | F | 82 | 925 | Cardiac/respiratory failure | VI | — | C | Definite AD | HlD |
| 14 | 1.5 | F | 85 | 850 | Failure to thrive | VI | — | C | Definite AD | HlD | |
| 15 | 1.5 | F | 79 | 950 | Cardiac/respiratory failure end stage | VI | — | C | Definite AD | HlD | |
| 16 | 1.83 | F | 84 | 1080 | End‐stage AD | VI | 00/30 | C | Definite AD | HlD | |
| 17 | 1.5 | F | 85 | 940 | Breast cancer; end‐stage AD | VI | 02/30 | C | Definite AD | HlD | |
| 18 | 4 | F | 82 | 932 | Failure to thrive; end‐stage AD | VI | 24/30 | C | Definite AD | HlD | |
| 19 | 2.33 | M | 77 | 1080 | End‐stage AD | VI | — | C | Definite AD | HlD | |
| 20 | 1.75 | M | 81 | 1150 | Pneumonia | VI | — | C | Definite AD | HlD | |
| 21 | 3.16 | M | 80 | 1000 | End‐stage AD | VI | 01/30 | C | Definite AD | HlD | |
| 22 | 3.5 | M | 77 | 1200 | End‐stage AD | VI | 04/30 | C | Definite AD | HlD | |
| 23 | 2.5 | M | 87 | 1100 | End‐stage AD | VI | 13/30 | C | Definite AD | HlD | |
| 24 | 2.25 | M | 78 | 1120 | End‐stage AD | VI | 07/30 | C | Definite AD | HlD | |
| Mean | 2.40 | 6/6 | 81.4 | 1027 |