Table 1.
1. UIP pattern (All four criteria) | 2. Probable UIP pattern | 3. Possible UIP pattern (All three criteria) | 4. Not UIP pattern (Any of the six criteria) |
---|---|---|---|
1. Marked fibrosis/architectural distortion, ± honeycombing in a predominantly subpleural/paraseptal distribution |
1. Marked fibrosis/architectural distortion, ± honeycombing |
1. Patch or diffuse involvement of lung parenchyma by fibrosis, with or without interstitial inflammation |
1. Hyaline membranes |
2. Organizing pneumonia | |||
3. Granulomas | |||
2. Presence of patchy involvement of lung parenchyma by fibrosis |
2. Absence of either patchy involvement or fibroblast foci, but not both |
2. Absence of other criteria for UIP (see UIP pattern column) |
4. Marked interstitial inflammatory cell infiltrate distant from honeycombing |
3. Presence of fibroblast foci |
3. Absence of features against a diagnosis of UIP suggesting an alternate diagnosis (see fourth column) |
3. Absence of features against a diagnosis of UIP suggesting an alternate diagnosis(see fourth column) |
5. Predominant airway centered changes |
4. Absence of features against a diagnosis of UIP suggesting an alternate diagnosis (see fourth column) |
OR |
|
6. Other features suggestive of an alternate diagnosis |
4. Honeycomb changes only |
Abbreviations:
IPF idiopathic pulmonary fibrosis.
UIP usual interstitial pneumonia.