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. Author manuscript; available in PMC: 2013 Apr 29.
Published in final edited form as: Autoimmunity. 2012 Apr 19;45(5):388–399. doi: 10.3109/08916934.2012.665523

Figure 3.

Figure 3

C57BL/6-Tg(IghelMD4)4Ccg/J (Jackson Laboratories, Bar Harbor, ME) and Vh186.2 BCR transgenic mice, which were kindly provided by Dr. M. Shlomchik, Yale University, New Haven, CT, were bred to B10.PLμMT mice to generate transgenic positive H-2uxu mice that were then intercrossed with transgenic negative mice to generate transgene positive μMT mice. EAE was induced as for Figure 1. A) Data are the mean daily scores of 9 B10.PL, 13 HEL-negative μMT (littermate control) and 15 HELμMT mice from two experiments for the B10.PL and three experiments for the μMT and HELμMT mice with 3-9 mice per group. B) Data are the mean daily scores of 3 B10.PL, 19 μMT and 18 Vh186.2 BCR mice from one experiment for the B10.PL and two experiments for the μMT and Vh186.2 BCR mice and each experiment contained 3–15 mice per group.