Fig. 4.

Sox10 is required for oligodendrocyte survival following axon wrapping. Frames captured from time-lapse movie of a cls^−/−; Tg(nkx2.2a:megfp) embryo beginning at about 60 hpf. Panels show lateral images of the spinal cord, with dorsal up. Numbers indicate time elapsed since the beginning of the sequence. Large arrow and arrowhead point to the soma of oligodendrocytes, and small arrows and arrowheads indicate initiation of axon wrapping. Oligodendrocytes begin to fragment and die following axon wrapping. Asterisk marks an OPC that migrated into the field of view following oligodendrocyte death. Scale bar, 24 μM.